童年孤独症发病机制及药物治疗进展

doi:10.3969/j.issn.2095-1396.2016.06. 006

摘要/Abstract

摘要： 童年孤独症（autism spectrum disorder，ASD），简称自闭症，多起病于儿童发育早期，以重复刻板行为、兴趣狭窄以及社交沟通障碍为主要临床诊断依据，伴有先天性大脑发育障碍，被归类为神经系统发育障碍性疾病。童年孤独症的病因极为复杂，与神经、遗传、免疫及环境等诸多因素相关。其中神经病理学、突触功能紊乱、炎症信号通路激活等分子机制均有报道参与介导童年孤独症的病理过程。由于发病机制不清，童年孤独症目前尚无有效治疗方法。该文通过查阅近年来国内外的相关文献，概述了自闭症发病机制研究进展，同时总结了目前针对童年孤独症患者行为障碍的临床用药现状，以期为儿童孤独症的进一步研究提供参考依据。

关键词: 童年孤独症, 发病机制, 药物治疗

Abstract: Autism spectrum disorder （ASD） is a heterogeneous group of bio-neurological developmental disorders that displays common behavioral symptoms， including pervasive impairments in social interactions， accompanied by communication challenges and repetitive behaviors. Present review highlighted the advances on molecular mechanisms of autism， also summary the present pharmacological interventions for abnormal symptoms during ASD clinical therapy.

Key words: autism spectrum disorder（ ASD）, molecular mechanism, drug therapy

龙森，陈嘉烨，韩峰. 童年孤独症发病机制及药物治疗进展[J]. 神经药理学报, 2016, 6(6): 55-64.

LONG Sen，CHEN Jia-ye，HAN Feng. Mechanisms of Autism Spectrum Disorder and Pharmacological Approach[J]. Acta Neuropharmacologica, 2016, 6(6): 55-64.

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